Yes, absolutely! Badly fitting wigs make any character look better. Of course the badly fitting hair doesn't have to be a wig...in fact, it's better if it's not. It can be the character's natural hair that just doesn't sit quite right on the head.
Even live action comedic actors (above) would benefit from wig-like hair. If you're Betty Boop or Cary Grant then the well-groomed wigless look is great, but really, how many people does that apply to? For most comedians real hair needs to have a life of its own. It should be willful and should require constant adjustment.
Be there or be square!